Malignant Hyperthermia
Malignant Hyperthermia Overview
Malignant Hyperthermia (MH) is a rare, inherited musculoskeletal syndrome that presents as a hypermetabolic reaction triggered by exposure to volatile anesthetic gases (e.g., desflurane, enflurane, halothane, sevoflurane) or the depolarizing muscle relaxant, succinylcholine.
The signs of MH include muscle rigidity, rapid heart rate, high body temperature, muscle breakdown, and increased acid content.
CRNAs/nurse anesthesiologists, resident registered nurse anesthetists, other clinicians, and facility administrators are encouraged to review available resources and assess their knowledge, preparedness, and training to periodically affirm the team’s readiness for an MH crisis.
Anesthesia professionals may be the first to recognize the onset of an MH crisis, but a coordinated team response is vital in the effective treatment and management of MH.
The Malignant Hyperthermia Association of the United States (MHAUS) has developed numerous resources and guidance for clinicians and patients to promote optimum care and scientific understanding of MH and related disorders. Jacqueline Sumanis, DNAP, CRNA is a member of the MHAUS Board of Directors.
MHAUS offers an emergency hotline for MH crises: 800-644-9737.
MHAUS also hosts the North American Malignant Hyperthermia Registry.
MHAUS Malignant Hyperthermia Resources
Preoperative Recommendations
Preoperative Recommendations
- Safe and Unsafe Anesthetics
- MH Susceptibility and Associated Conditions
- Stocking an MH Cart
- Preparation of Anesthesia Workstations to Anesthetize MH Susceptible Patients
- Preparation of the Drager Fabius Anesthesia Machine for the Malignant-Hyperthermia Susceptible Patient, Anesthesia & Analgesia, January 2012
Intraoperative Recommendations
Intraoperative Recommendations
- Emergency Treatment for an Acute MH Event
- FAQs – Management of MH-Susceptible Patients
- The Current Status of Malignant Hyperthermia, The Journal of Biomedical Research, March 2020
Postoperative Recommendations
Postoperative Recommendations
Patient Transfer
Patient Transfer
- Creation of a Guide for the Transfer of Care of the Malignant Hyperthermia Patient from Ambulatory Surgery Centers to Receiving Hospital Facilities, Anesthesia & Analgesia, January 2012
Disclaimer
The resources on this page may incorporate or summarize views, guidelines, or recommendations of third parties. Such material is assembled and presented in good faith, but does not necessarily reflect the views of the AANA. Links to third-party websites are inserted for informational purposes and do not constitute endorsement of the material on those sites, or of any associated organization.